Cor Vasa 2005, 46(10):395-398
Setting reference values for BNP and NT-proBNP
- 1 Interní-kardiologická klinika, Fakultní nemocnice Brno
- 2 I. interní-kardioangiologická klinika, Fakultní nemocnice u sv. Anny, Brno, Česká republika
The authors present the ever first reference values for BNP and NT-proBNP as diagnostic and prognostic tools in patients with heart failure. Different reference values have been proposed for acute heart failure and for chronic heart failure. BNP > 100 pg/ml and NT-proBNP > 125 pg/ml are diagnostic for chronic heart failure. BNP > 500 pg/ml and NT-proBNP > 1 800 pg/ml are indicative of acute heart failure, NT-proBNP > 450 pg/ml in younger patients could signal acute heart failure. Neither BNP nor NT-proBNP are suitable for the diagnosis of asymptomatic diastolic dysfunction or left ventricular hypertrophy, but they are most valuable in the differential diagnosis of symptomatic left ventricular systolic dysfunction.
Keywords: BNP; NT-proBNP; Heart failure; Normal values
Published: October 1, 2005 Show citation