Cor Vasa 2026, 68(4):440-447 | DOI: 10.33678/cor.2025.120

The Value of Hypoxia Inducible Factor 1 alpha as a Biomarker for Stable Coronary Artery Disease Diagnosis and Risk Stratification.

Ahmed G. Bakrya, Hossam Eldin M. Mahmouda, M. Abdelsayeda, Mustafa M. Alia, Enas Fathyb, Omyma Ashrafc, Mohammed H. Hassanc
a Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Qena University, Qena, Egypt
b Cardiology Department, Faculty of Medicine, Aswan University, Aswan, Egypt
c Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Qena University, Qena, Egypt

Background: Stable coronary artery disease (CAD) is a worldwide health concern, and trustworthy biomarkers for CAD diagnosis and risk assessment are still being investigated. The primary regulator of the cellular response to hypoxia, hypoxia inducible factor 1 alpha (HIF-1α), has been thoroughly investigated in the context of acute cardiovascular events; however, its function as a biomarker in stable CAD is less well-established and requires validation.

Objectives: To evaluate the diagnostic and prognostic significance of HIF-1α in stable CAD and its correlation with disease severity. © 2026, ČKS.

Keywords: Biomarkers, Cardiovascular risk factors, Hypoxia-inducible factor 1-alpha, Stable coronary artery disease.

Received: November 14, 2025; Revised: November 14, 2025; Accepted: November 16, 2025; Prepublished online: August 24, 2026; Published: August 31, 2026  Show citation

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Bakry AG, Eldin Mahmoud HM, Abdelsayed M, Ali MM, Fathy E, Ashraf O, Hassan MH. The Value of Hypoxia Inducible Factor 1 alpha as a Biomarker for Stable Coronary Artery Disease Diagnosis and Risk Stratification. Cor Vasa. 2026;68(4):440-447. doi: 10.33678/cor.2025.120.
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